Rab GDP dissociation inhibitor alpha (GDI1)

About Rab GDP dissociation inhibitor alpha

Rab GDP dissociation inhibitor alpha (GDI1) is a protein from Homo sapiens identified by UniProt accession P31150, 447 residues long. MolForge cross-references it against 0 known binders and 162 disease associations.

Target properties

Protein name	Rab GDP dissociation inhibitor alpha
UniProt accession	P31150
Gene	GDI1
Organism	Homo sapiens
Length	447 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (162)

Diseases linked to this target (Open Targets).

X-linked non-syndromic intellectual disability · score 0.74
Intellectual disability · score 0.37
multiple sclerosis · score 0.34
Parkinson disease · score 0.34
lysosomal storage disease · score 0.34
Alzheimer disease · score 0.34
neurodegenerative disease · score 0.34
genetic disorder · score 0.33
non-syndromic X-linked intellectual disability · score 0.31
cardiac hypertrophy · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31150-F1	alphafold	PREDICTED	93.36	—

Amino-acid sequence (447 residues)

MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE ELYKRFQLLE GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL DFKVVEGSFV YKGGKIYKVP STETEALASN LMGMFEKRRF RKFLVFVANF DENDPKTFEG VDPQTTSMRD VYRKFDLGQD VIDFTGHALA LYRTDDYLDQ PCLETVNRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI AIASTTVETT DPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGCESQVFC SCSYDATTHF ETTCNDIKDI YKRMAGTAFD FENMKRKQND VFGEAEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards