About Mitogen-activated protein kinase 4
Mitogen-activated protein kinase 4 (MAPK4) is a protein
from Homo sapiens identified by UniProt accession
P31152, 587 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase 4 |
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| UniProt accession | P31152 |
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| Gene | MAPK4 |
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| Organism | Homo sapiens |
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| Length | 587 residues |
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| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (83)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.50
- leukocyte count · score 0.50
- monocyte count · score 0.49
- diastolic blood pressure · score 0.48
- systolic blood pressure · score 0.48
- myeloid white cell count · score 0.45
- BMI-adjusted waist-hip ratio · score 0.42
- mean arterial pressure · score 0.34
- sum of basophil and neutrophil counts · score 0.33
- granulocyte count · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31152-F1 | alphafold | PREDICTED | 63.53 | — |
Amino-acid sequence (587 residues)
MAEKGDCIAS VYGYDLGGRF VDFQPLGFGV NGLVLSAVDS RACRKVAVKK IALSDARSMK HALREIKIIR RLDHDNIVKV YEVLGPKGTD LQGELFKFSV AYIVQEYMET DLARLLEQGT LAEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL ILETIPVIRE EDKDELLRVM PSFVSSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR LTAEMGLQHP YMSPYSCPED EPTSQHPFRI EDEIDDIVLM AANQSQLSNW DTCSSRYPVS LSSDLEWRPD RCQDASEVQR DPRAGSAPLA EDVQVDPRKD SHSSSERFLE QSHSSMERAF EADYGRSCDY KVGSPSYLDK LLWRDNKPHH YSEPKLILDL SHWKQAAGAP PTATGLADTG AREDEPASLF LEIAQWVKST QGGPEHASPP ADDPERRLSA SPPGRPAPVD GGASPQFDLD VFISRALKLC TKPEDLPDNK LGDLNGACIP EHPGDLVQTE AFSKERW
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