S-adenosylmethionine synthase isoform type-2 (MAT2A)

About S-adenosylmethionine synthase isoform type-2

S-adenosylmethionine synthase isoform type-2 (MAT2A) is a protein from Homo sapiens identified by UniProt accession P31153, 395 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	S-adenosylmethionine synthase isoform type-2
UniProt accession	P31153
Gene	MAT2A
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (158)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
platelet count · score 0.35
neuroinflammatory disorder · score 0.34
prostate carcinoma · score 0.28
coronary artery disease · score 0.28
platelet crit · score 0.26
angina pectoris · score 0.26
Myocardial Ischemia · score 0.23
sitting height measurement · score 0.22
myocardial infarction · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31153-F1	alphafold	PREDICTED	96.06	—

Amino-acid sequence (395 residues)

MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards