About Homeobox protein Hox-D3
Homeobox protein Hox-D3 (HOXD3) is a protein
from Homo sapiens identified by UniProt accession
P31249, 432 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Homeobox protein Hox-D3 |
|---|
| UniProt accession | P31249 |
|---|
| Gene | HOXD3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 432 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (117)
Diseases linked to this target (Open Targets).
- body height · score 0.28
- ovarian carcinoma · score 0.27
- ovarian serous carcinoma · score 0.26
- systolic blood pressure · score 0.25
- ovarian mucinous adenocarcinoma · score 0.24
- FEV/FVC ratio · score 0.24
- endometrial cancer · score 0.23
- breast adenocarcinoma · score 0.22
- pulse pressure measurement · score 0.22
- diastolic blood pressure · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31249-F1 | alphafold | PREDICTED | 56.33 | — |
Amino-acid sequence (432 residues)
MLFEQGQQAL ELPECTMQKA AYYENPGLFG GYGYSKTTDT YGYSTPHQPY PPPAAASSLD TDYPGSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG GGGGSQPPGL NSEQQPPQPP PPPPTLPPSS PTNPGGGVPA KKPKGGPNAS SSSATISKQI FPWMKESRQN SKQKNSCATA GESCEDKSPP GPASKRVRTA YTSAQLVELE KEFHFNRYLC RPRRVEMANL LNLTERQIKI WFQNRRMKYK KDQKAKGILH SPASQSPERS PPLGGAAGHV AYSGQLPPVP GLAYDAPSPP AFAKSQPNMY GLAAYTAPLS SCLPQQKRYA APEFEPHPMA SNGGGFASAN LQGSPVYVGG NFVESMAPAS GPVFNLGHLS HPSSASVDYS CAAQIPGNHH HGPCDPHPTY TDLSAHHSSQ GRLPEAPKLT HL
Explore Homeobox protein Hox-D3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets