Homeobox protein Hox-A11 (HOXA11)

About Homeobox protein Hox-A11

Homeobox protein Hox-A11 (HOXA11) is a protein from Homo sapiens identified by UniProt accession P31270, 313 residues long. MolForge cross-references it against 0 known binders and 558 disease associations.

Target properties

Protein name	Homeobox protein Hox-A11
UniProt accession	P31270
Gene	HOXA11
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (558)

Diseases linked to this target (Open Targets).

Radio-ulnar synostosis - amegakaryocytic thrombocytopenia · score 0.57
BMI-adjusted waist-hip ratio · score 0.40
radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome · score 0.38
colorectal adenocarcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
physical activity measurement · score 0.36
waist-hip ratio · score 0.35
neurodegenerative disease · score 0.35
BMI-adjusted waist circumference · score 0.34
non-small cell lung carcinoma · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31270-F1	alphafold	PREDICTED	59.85	—

Amino-acid sequence (313 residues)

MDFDERGPCS SNMYLPSCTY YVSGPDFSSL PSFLPQTPSS RPMTYSYSSN LPQVQPVREV TFREYAIEPA TKWHPRGNLA HCYSAEELVH RDCLQAPSAA GVPGDVLAKS SANVYHHPTP AVSSNFYSTV GRNGVLPQAF DQFFETAYGT PENLASSDYP GDKSAEKGPP AATATSAAAA AAATGAPATS SSDSGGGGGC RETAAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSSGQR TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN RDRLQYYSAN PLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards