About Homeobox protein Hox-C8
Homeobox protein Hox-C8 (HOXC8) is a protein
from Homo sapiens identified by UniProt accession
P31273, 242 residues long.
MolForge cross-references it against 0 known binders and
252 disease associations.
Target properties
| Protein name | Homeobox protein Hox-C8 |
|---|
| UniProt accession | P31273 |
|---|
| Gene | HOXC8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 242 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (252)
Diseases linked to this target (Open Targets).
- platelet count · score 0.11
- non-small cell lung carcinoma · score 0.10
- heel bone mineral density · score 0.10
- neoplasm · score 0.09
- platelet crit · score 0.09
- BMI-adjusted waist circumference · score 0.09
- peak expiratory flow · score 0.09
- FEV/FVC ratio · score 0.08
- breast cancer · score 0.08
- intrahepatic cholangiocarcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31273-F1 | alphafold | PREDICTED | 64.14 | — |
Amino-acid sequence (242 residues)
MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD
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