About Homeobox protein Hox-C12
Homeobox protein Hox-C12 (HOXC12) is a protein
from Homo sapiens identified by UniProt accession
P31275, 282 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Homeobox protein Hox-C12 |
|---|
| UniProt accession | P31275 |
|---|
| Gene | HOXC12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 282 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.36
- smoking behavior · score 0.32
- BMI-adjusted hip circumference · score 0.27
- physical activity measurement · score 0.24
- age at assessment · score 0.24
- sex interaction measurement · score 0.24
- waist-hip ratio · score 0.22
- adolescent idiopathic scoliosis · score 0.11
- hemorrhoid · score 0.09
- essential tremor · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31275-F1 | alphafold | PREDICTED | 61.40 | — |
Amino-acid sequence (282 residues)
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLSWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA EGGGGGLKRE ERGRDPGAGP GAALLPLEPS GPPALGFKYD YAAGGGGGDG GGGAGPPHDP PSCQSLESDS SSSLLNEGNK GAGAGDPGSL VSPLNPGGGL SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT RQRRRELSDR LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF
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