Homeobox protein Hox-C13 (HOXC13)

About Homeobox protein Hox-C13

Homeobox protein Hox-C13 (HOXC13) is a protein from Homo sapiens identified by UniProt accession P31276, 330 residues long. MolForge cross-references it against 0 known binders and 250 disease associations.

Target properties

Protein name	Homeobox protein Hox-C13
UniProt accession	P31276
Gene	HOXC13
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (250)

Diseases linked to this target (Open Targets).

pure hair and nail ectodermal dysplasia · score 0.71
colorectal adenocarcinoma · score 0.37
hair color · score 0.34
hair shape measurement · score 0.31
melanoma · score 0.29
oral squamous cell carcinoma · score 0.29
head and neck squamous cell carcinoma · score 0.28
skin basal cell carcinoma · score 0.28
lung adenocarcinoma · score 0.28
gastric adenocarcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31276-F1	alphafold	PREDICTED	57.28	—

Amino-acid sequence (330 residues)

MTTSLLLHPR WPESLMYVYE DSAAESGIGG GGGGGGGGTG GAGGGCSGAS PGKAPSMDGL GSSCPASHCR DLLPHPVLGR PPAPLGAPQG AVYTDIPAPE AARQCAPPPA PPTSSSATLG YGYPFGGSYY GCRLSHNVNL QQKPCAYHPG DKYPEPSGAL PGDDLSSRAK EFAFYPSFAS SYQAMPGYLD VSVVPGISGH PEPRHDALIP VEGYQHWALS NGWDSQVYCS KEQSQSAHLW KSPFPDVVPL QPEVSSYRRG RKKRVPYTKV QLKELEKEYA ASKFITKEKR RRISATTNLS ERQVTIWFQN RRVKEKKVVS KSKAPHLHST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards