Homeobox protein Hox-D11 (HOXD11)

About Homeobox protein Hox-D11

Homeobox protein Hox-D11 (HOXD11) is a protein from Homo sapiens identified by UniProt accession P31277, 338 residues long. MolForge cross-references it against 0 known binders and 439 disease associations.

Target properties

Protein name	Homeobox protein Hox-D11
UniProt accession	P31277
Gene	HOXD11
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (439)

Diseases linked to this target (Open Targets).

gastric carcinoma · score 0.37
colon adenocarcinoma · score 0.37
colorectal adenocarcinoma · score 0.37
heel bone mineral density · score 0.36
lung carcinoma · score 0.28
urinary bladder carcinoma · score 0.28
breast carcinoma · score 0.28
cutaneous melanoma · score 0.28
clear cell renal carcinoma · score 0.28
hepatocellular carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31277-F1	alphafold	PREDICTED	57.88	—

Amino-acid sequence (338 residues)

MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA GGYAPYYAAA AAAAAAAAAA EEAAMQRELL PPAGRRPDVL FKAPEPVCAA PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ FYEAAPGPPF AGPQPPPPPA PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG SGGDGEGPPG EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards