About cAMP-dependent protein kinase type II-beta regulatory subunit
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) is a protein
from Homo sapiens identified by UniProt accession
P31323, 418 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | cAMP-dependent protein kinase type II-beta regulatory subunit |
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| UniProt accession | P31323 |
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| Gene | PRKAR2B |
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| Organism | Homo sapiens |
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| Length | 418 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (146)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.37
- mean corpuscular hemoglobin concentration · score 0.37
- blood urea nitrogen measurement · score 0.34
- serum urea measurement · score 0.27
- ovarian cancer · score 0.25
- triglyceride measurement · score 0.25
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.23
- esophageal cancer · score 0.15
- serum albumin measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31323-F1 | alphafold | PREDICTED | 78.70 | — |
Amino-acid sequence (418 residues)
MSIEIPAGLT ELLQGFTVEV LRHQPADLLE FALQHFTRLQ QENERKGTAR FGHEGRTWGD LGAAAGGGTP SKGVNFAEEP MQSDSEDGEE EEAAPADAGA FNAPVINRFT RRASVCAEAY NPDEEEDDAE SRIIHPKTDD QRNRLQEACK DILLFKNLDP EQMSQVLDAM FEKLVKDGEH VIDQGDDGDN FYVIDRGTFD IYVKCDGVGR CVGNYDNRGS FGELALMYNT PRAATITATS PGALWGLDRV TFRRIIVKNN AKKRKMYESF IESLPFLKSL EFSERLKVVD VIGTKVYNDG EQIIAQGDSA DSFFIVESGE VKITMKRKGK SEVEENGAVE IARCSRGQYF GELALVTNKP RAASAHAIGT VKCLAMDVQA FERLLGPCME IMKRNIATYE EQLVALFGTN MDIVEPTA
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