Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

About Ribonucleoside-diphosphate reductase subunit M2

Ribonucleoside-diphosphate reductase subunit M2 (RRM2) is a protein from Homo sapiens identified by UniProt accession P31350, 389 residues long. MolForge cross-references it against 0 known binders and 336 disease associations.

Target properties

Protein name	Ribonucleoside-diphosphate reductase subunit M2
UniProt accession	P31350
Gene	RRM2
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (336)

Diseases linked to this target (Open Targets).

sickle cell anemia · score 0.58
melanoma · score 0.56
neurodegenerative disease · score 0.53
polycythemia vera · score 0.51
essential thrombocythemia · score 0.50
HIV infection · score 0.46
chronic myelogenous leukemia · score 0.44
neoplasm · score 0.41
leukemia · score 0.39
Thalassemia · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31350-F1	alphafold	PREDICTED	79.71	—

Amino-acid sequence (389 residues)

MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards