Calsequestrin-1 (CASQ1)

About Calsequestrin-1

Calsequestrin-1 (CASQ1) is a protein from Homo sapiens identified by UniProt accession P31415, 396 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Calsequestrin-1
UniProt accession	P31415
Gene	CASQ1
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

myopathy due to calsequestrin and SERCA1 protein overload · score 0.61
myopathy, tubular aggregate, 1 · score 0.46
tubular aggregate myopathy · score 0.38
grip strength measurement · score 0.30
genetic disorder · score 0.19
myopathy · score 0.13
body fat percentage · score 0.09
Distal myopathy, Nonaka type · score 0.05
paramyotonia congenita of Von Eulenburg · score 0.05
autosomal recessive limb-girdle muscular dystrophy type 2L · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31415-F1	alphafold	PREDICTED	89.99	—

Amino-acid sequence (396 residues)

MSATDRMGPR AVPGLRLALL LLLVLGTPKS GVQGQEGLDF PEYDGVDRVI NVNAKNYKNV FKKYEVLALL YHEPPEDDKA SQRQFEMEEL ILELAAQVLE DKGVGFGLVD SEKDAAVAKK LGLTEVDSMY VFKGDEVIEY DGEFSADTIV EFLLDVLEDP VELIEGEREL QAFENIEDEI KLIGYFKSKD SEHYKAFEDA AEEFHPYIPF FATFDSKVAK KLTLKLNEID FYEAFMEEPV TIPDKPNSEE EIVNFVEEHR RSTLRKLKPE SMYETWEDDM DGIHIVAFAE EADPDGFEFL ETLKAVAQDN TENPDLSIIW IDPDDFPLLV PYWEKTFDID LSAPQIGVVN VTDADSVWME MDDEEDLPSA EELEDWLEDV LEGEINTEDD DDDDDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards