About Cytotoxic granule associated RNA binding protein TIA1
Cytotoxic granule associated RNA binding protein TIA1 (TIA1) is a protein
from Homo sapiens identified by UniProt accession
P31483, 386 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Cytotoxic granule associated RNA binding protein TIA1 |
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| UniProt accession | P31483 |
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| Gene | TIA1 |
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| Organism | Homo sapiens |
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| Length | 386 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (260)
Diseases linked to this target (Open Targets).
- amyotrophic lateral sclerosis 26 with or without frontotemporal dementia · score 0.66
- distal myopathy, Welander type · score 0.65
- lung adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.23
- breast adenocarcinoma · score 0.23
- sex hormone-binding globulin measurement · score 0.19
- cutaneous melanoma · score 0.18
- genetic disorder · score 0.16
- testosterone measurement · score 0.10
- insulin like growth factor measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31483-F1 | alphafold | PREDICTED | 73.68 | — |
Amino-acid sequence (386 residues)
MEDEMPKTLY VGNLSRDVTE ALILQLFSQI GPCKNCKMIM DTAGNDPYCF VEFHEHRHAA AALAAMNGRK IMGKEVKVNW ATTPSSQKKD TSSSTVVSTQ RSQDHFHVFV GDLSPEITTE DIKAAFAPFG RISDARVVKD MATGKSKGYG FVSFFNKWDA ENAIQQMGGQ WLGGRQIRTN WATRKPPAPK STYESNTKQL SYDEVVNQSS PSNCTVYCGG VTSGLTEQLM RQTFSPFGQI MEIRVFPDKG YSFVRFNSHE SAAHAIVSVN GTTIEGHVVK CYWGKETLDM INPVQQQNQI GYPQPYGQWG QWYGNAQQIG QYMPNGWQVP AYGMYGQAWN QQGFNQTQSS APWMGPNYGV QPPQGQNGSM LPNQPSGYRV AGYETQ
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