About Dimethylaniline monooxygenase [N-oxide-forming] 4
Dimethylaniline monooxygenase [N-oxide-forming] 4 (FMO4) is a protein
from Homo sapiens identified by UniProt accession
P31512, 558 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Dimethylaniline monooxygenase [N-oxide-forming] 4 |
|---|
| UniProt accession | P31512 |
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| Gene | FMO4 |
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| Organism | Homo sapiens |
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| Length | 558 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- urinary metabolite measurement · score 0.39
- brain aneurysm · score 0.31
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.27
- platelet component distribution width · score 0.19
- trimethylaminuria · score 0.12
- neutrophil count · score 0.04
- myeloid white cell count · score 0.03
- creatinine measurement · score 0.03
- clear cell renal carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31512-F1 | alphafold | PREDICTED | 91.51 | — |
Amino-acid sequence (558 residues)
MAKKVAVIGA GVSGLSSIKC CVDEDLEPTC FERSDDIGGL WKFTESSKDG MTRVYKSLVT NVCKEMSCYS DFPFHEDYPN FMNHEKFWDY LQEFAEHFDL LKYIQFKTTV CSITKRPDFS ETGQWDVVTE TEGKQNRAVF DAVMVCTGHF LNPHLPLEAF PGIHKFKGQI LHSQEYKIPE GFQGKRVLVI GLGNTGGDIA VELSRTAAQV LLSTRTGTWV LGRSSDWGYP YNMMVTRRCC SFIAQVLPSR FLNWIQERKL NKRFNHEDYG LSITKGKKAK FIVNDELPNC ILCGAITMKT SVIEFTETSA VFEDGTVEEN IDVVIFTTGY TFSFPFFEEP LKSLCTKKIF LYKQVFPLNL ERATLAIIGL IGLKGSILSG TELQARWVTR VFKGLCKIPP SQKLMMEATE KEQLIKRGVF KDTSKDKFDY IAYMDDIAAC IGTKPSIPLL FLKDPRLAWE VFFGPCTPYQ YRLMGPGKWD GARNAILTQW DRTLKPLKTR IVPDSSKPAS MSHYLKAWGA PVLLASLLLI CKSSLFLKLV RDKLQDRMSP YLVSLWRG
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