About Flavin-containing monooxygenase 3
Flavin-containing monooxygenase 3 (FMO3) is a protein
from Homo sapiens identified by UniProt accession
P31513, 532 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Flavin-containing monooxygenase 3 |
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| UniProt accession | P31513 |
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| Gene | FMO3 |
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| Organism | Homo sapiens |
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| Length | 532 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (121)
Diseases linked to this target (Open Targets).
- trimethylaminuria · score 0.72
- Trimethylaminuria · score 0.56
- sex hormone-binding globulin measurement · score 0.43
- inborn errors of metabolism · score 0.37
- serum metabolite measurement · score 0.35
- genetic disorder · score 0.34
- low density lipoprotein cholesterol measurement · score 0.33
- apolipoprotein B measurement · score 0.29
- total cholesterol measurement · score 0.28
- blood metabolite measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31513-F1 | alphafold | PREDICTED | 95.64 | — |
Amino-acid sequence (532 residues)
MGKKVAIIGA GVSGLASIRS CLEEGLEPTC FEKSNDIGGL WKFSDHAEEG RASIYKSVFS NSSKEMMCFP DFPFPDDFPN FMHNSKIQEY IIAFAKEKNL LKYIQFKTFV SSVNKHPDFA TTGQWDVTTE RDGKKESAVF DAVMVCSGHH VYPNLPKESF PGLNHFKGKC FHSRDYKEPG VFNGKRVLVV GLGNSGCDIA TELSRTAEQV MISSRSGSWV MSRVWDNGYP WDMLLVTRFG TFLKNNLPTA ISDWLYVKQM NARFKHENYG LMPLNGVLRK EPVFNDELPA SILCGIVSVK PNVKEFTETS AIFEDGTIFE GIDCVIFATG YSFAYPFLDE SIIKSRNNEI ILFKGVFPPL LEKSTIAVIG FVQSLGAAIP TVDLQSRWAA QVIKGTCTLP SMEDMMNDIN EKMEKKRKWF GKSETIQTDY IVYMDELSSF IGAKPNIPWL FLTDPKLAME VYFGPCSPYQ FRLVGPGQWP GARNAILTQW DRSLKPMQTR VVGRLQKPCF FFHWLKLFAI PILLIAVFLV LT
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