About Sodium/glucose cotransporter 2
Sodium/glucose cotransporter 2 (SLC5A2) is a protein
from Homo sapiens identified by UniProt accession
P31639, 672 residues long.
MolForge cross-references it against 0 known binders and
719 disease associations.
Target properties
| Protein name | Sodium/glucose cotransporter 2 |
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| UniProt accession | P31639 |
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| Gene | SLC5A2 |
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| Organism | Homo sapiens |
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| Length | 672 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (719)
Diseases linked to this target (Open Targets).
- familial renal glucosuria · score 0.69
- type 2 diabetes mellitus · score 0.63
- diabetes mellitus · score 0.63
- chronic kidney disease · score 0.61
- type 1 diabetes mellitus · score 0.60
- Renal glucosuria · score 0.60
- heart failure · score 0.60
- Disorder of carbohydrate metabolism · score 0.57
- non-alcoholic fatty liver disease · score 0.55
- IGA glomerulonephritis · score 0.54
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31639-F1 | alphafold | PREDICTED | 83.79 | — |
Amino-acid sequence (672 residues)
MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA GVITMPQYLR KRFGGRRIRL YLSVLSLFLY IFTKISVDMF SGAVFIQQAL GWNIYASVIA LLGITMIYTV TGGLAALMYT DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL TVSEDPAVGN ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV CRRVCGTEVG CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS SSTLFTMDIY TRLRPRAGDR ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG QLFDYIQAVS SYLAPPVSAV FVLALFVPRV NEQGAFWGLI GGLLMGLARL IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL TLTVSLCTAP IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNEPQ APAPSLFRQC LLWFCGMSRG GVGSPPPLTQ EEAAAAARRL EDISEDPSWA RVVNLNALLM MAVAVFLWGF YA
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