About Sodium- and chloride-dependent taurine transporter
Sodium- and chloride-dependent taurine transporter (SLC6A6) is a protein
from Homo sapiens identified by UniProt accession
P31641, 620 residues long.
MolForge cross-references it against 0 known binders and
308 disease associations.
Target properties
| Protein name | Sodium- and chloride-dependent taurine transporter |
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| UniProt accession | P31641 |
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| Gene | SLC6A6 |
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| Organism | Homo sapiens |
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| Length | 620 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (308)
Diseases linked to this target (Open Targets).
- cardiomyopathy · score 0.42
- testosterone measurement · score 0.39
- retinal degeneration · score 0.34
- systolic blood pressure · score 0.30
- body height · score 0.27
- chronotype measurement · score 0.26
- mean platelet volume · score 0.26
- PHF-tau measurement · score 0.25
- cutaneous melanoma · score 0.18
- lymphocyte percentage of leukocytes · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31641-F1 | alphafold | PREDICTED | 86.82 | — |
Amino-acid sequence (620 residues)
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII IGQYTSEGGI TCWEKICPLF SGIGYASVVI VSLLNVYYIV ILAWATYYLF QSFQKELPWA HCNHSWNTPH CMEDTMRKNK SVWITISSTN FTSPVIEFWE RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAFVCSISY LLGLTMVTEG GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP GPWMKYSWAV ITPVLCVGCF IFSLVKYVPL TYNKTYVYPN WAIGLGWSLA LSSMLCVPLV IVIRLCQTEG PFLVRVKYLL TPREPNRWAV EREGATPYNS RTVMNGALVK PTHIIVETMM
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