About Gamma-aminobutyric acid receptor subunit alpha-5
Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) is a protein
from Homo sapiens identified by UniProt accession
P31644, 462 residues long.
MolForge cross-references it against 0 known binders and
404 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit alpha-5 |
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| UniProt accession | P31644 |
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| Gene | GABRA5 |
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| Organism | Homo sapiens |
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| Length | 462 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (404)
Diseases linked to this target (Open Targets).
- Seizure · score 0.63
- unipolar depression · score 0.61
- epilepsy · score 0.61
- panic disorder · score 0.61
- insomnia · score 0.61
- Agitation · score 0.60
- anxiety · score 0.60
- anxiety disorder · score 0.60
- pain · score 0.60
- delirium · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31644-F1 | alphafold | PREDICTED | 81.00 | — |
Amino-acid sequence (462 residues)
MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT RILDGLLDGY DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF RQSWKDERLR FKGPMQRLPL NNLLASKIWT PDTFFHNGKK SIAHNMTTPN KLLRLEDDGT LLYTMRLTIS AECPMQLEDF PMDAHACPLK FGSYAYPNSE VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS TGEYTIMTAH FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA WDGKKALEAA KIKKKREVIL NKSTNAFTTG KMSHPPNIPK EQTPAGTSNT TSVSVKPSEE KTSESKKTYN SISKIDKMSR IVFPVLFGTF NLVYWATYLN REPVIKGAAS PK
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