DnaJ homolog subfamily A member 1 (DNAJA1)

About DnaJ homolog subfamily A member 1

DnaJ homolog subfamily A member 1 (DNAJA1) is a protein from Homo sapiens identified by UniProt accession P31689, 397 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	DnaJ homolog subfamily A member 1
UniProt accession	P31689
Gene	DNAJA1
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.20
age at menopause · score 0.12
reticulocyte measurement · score 0.11
self reported educational attainment · score 0.11
azoospermia · score 0.08
cancer · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.06
partial chromosome Y deletion · score 0.06
urate measurement · score 0.05
spermatogenic failure 63 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31689-F1	alphafold	PREDICTED	83.26	—

Amino-acid sequence (397 residues)

MVKETTYYDV LGVKPNATQE ELKKAYRKLA LKYHPDKNPN EGEKFKQISQ AYEVLSDAKK RELYDKGGEQ AIKEGGAGGG FGSPMDIFDM FFGGGGRMQR ERRGKNVVHQ LSVTLEDLYN GATRKLALQK NVICDKCEGR GGKKGAVECC PNCRGTGMQI RIHQIGPGMV QQIQSVCMEC QGHGERISPK DRCKSCNGRK IVREKKILEV HIDKGMKDGQ KITFHGEGDQ EPGLEPGDII IVLDQKDHAV FTRRGEDLFM CMDIQLVEAL CGFQKPISTL DNRTIVITSH PGQIVKHGDI KCVLNEGMPI YRRPYEKGRL IIEFKVNFPE NGFLSPDKLS LLEKLLPERK EVEETDEMDQ VELVDFDPNQ ERRRHYNGEA YEDDEHHPRG GVQCQTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards