About RAC-beta serine/threonine-protein kinase
RAC-beta serine/threonine-protein kinase (AKT2) is a protein
from Homo sapiens identified by UniProt accession
P31751, 481 residues long.
MolForge cross-references it against 0 known binders and
558 disease associations.
Target properties
| Protein name | RAC-beta serine/threonine-protein kinase |
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| UniProt accession | P31751 |
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| Gene | AKT2 |
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| Organism | Homo sapiens |
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| Length | 481 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (558)
Diseases linked to this target (Open Targets).
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.75
- type 2 diabetes mellitus · score 0.71
- cancer · score 0.47
- breast cancer · score 0.42
- cutaneous melanoma · score 0.41
- prostate carcinoma · score 0.39
- neurodegenerative disease · score 0.39
- AKT2-related familial partial lipodystrophy · score 0.38
- carcinoma of liver and intrahepatic biliary tract · score 0.38
- lung carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31751-F1 | alphafold | PREDICTED | 82.27 | — |
Amino-acid sequence (481 residues)
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM DYKCGSPSDS STTEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH LSRERVFTEE RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG LLELDQRTHF PQFSYSASIR E
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