Cytokine receptor common subunit gamma (IL2RG)

About Cytokine receptor common subunit gamma

Cytokine receptor common subunit gamma (IL2RG) is a protein from Homo sapiens identified by UniProt accession P31785, 369 residues long. MolForge cross-references it against 0 known binders and 543 disease associations.

Target properties

Protein name	Cytokine receptor common subunit gamma
UniProt accession	P31785
Gene	IL2RG
Organism	Homo sapiens
Length	369 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (543)

Diseases linked to this target (Open Targets).

gamma chain deficiency · score 0.84
X-Linked Combined Immunodeficiency Diseases · score 0.72
Omenn syndrome · score 0.56
severe combined immunodeficiency · score 0.47
T-B+ severe combined immunodeficiency · score 0.46
genetic disorder · score 0.44
breast adenocarcinoma · score 0.29
neurodegenerative disease · score 0.28
endometrial cancer · score 0.27
lung adenocarcinoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31785-F1	alphafold	PREDICTED	75.52	—

Amino-acid sequence (369 residues)

MLKPSLPFTS LLFLQLPLLG VGLNTTILTP NGNEDTTADF FLTTMPTDSL SVSTLPLPEV QCFVFNVEYM NCTWNSSSEP QPTNLTLHYW YKNSDNDKVQ KCSHYLFSEE ITSGCQLQKK EIHLYQTFVV QLQDPREPRR QATQMLKLQN LVIPWAPENL TLHKLSESQL ELNWNNRFLN HCLEHLVQYR TDWDHSWTEQ SVDYRHKFSL PSVDGQKRYT FRVRSRFNPL CGSAQHWSEW SHPIHWGSNT SKENPFLFAL EAVVISVGSM GLIISLLCVY FWLERTMPRI PTLKNLEDLV TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP PCYTLKPET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards