About Cytochrome b-c1 complex subunit 1, mitochondrial
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) is a protein
from Homo sapiens identified by UniProt accession
P31930, 480 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Cytochrome b-c1 complex subunit 1, mitochondrial |
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| UniProt accession | P31930 |
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| Gene | UQCRC1 |
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| Organism | Homo sapiens |
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| Length | 480 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- parkinsonism with polyneuropathy · score 0.58
- neurodegenerative disease · score 0.57
- Parkinson disease · score 0.51
- Alzheimer disease · score 0.50
- multiple sclerosis · score 0.50
- lysosomal storage disease · score 0.50
- hypertrophic cardiomyopathy · score 0.26
- platelet crit · score 0.17
- mean corpuscular volume · score 0.15
- mean reticulocyte volume · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31930-F1 | alphafold | PREDICTED | 91.45 | — |
Amino-acid sequence (480 residues)
MAASVVCRAA TAGAQVLLRA RRSPALLRTP ALRSTATFAQ ALQFVPETQV SLLDNGLRVA SEQSSQPTCT VGVWIDVGSR FETEKNNGAG YFLEHLAFKG TKNRPGSALE KEVESMGAHL NAYSTREHTA YYIKALSKDL PKAVELLGDI VQNCSLEDSQ IEKERDVILR EMQENDASMR DVVFNYLHAT AFQGTPLAQA VEGPSENVRK LSRADLTEYL STHYKAPRMV LAAAGGVEHQ QLLDLAQKHL GGIPWTYAED AVPTLTPCRF TGSEIRHRDD ALPFAHVAIA VEGPGWASPD NVALQVANAI IGHYDCTYGG GVHLSSPLAS GAVANKLCQS FQTFSICYAE TGLLGAHFVC DRMKIDDMMF VLQGQWMRLC TSATESEVAR GKNILRNALV SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIAEVDASV VREICSKYIY DQCPAVAGYG PIEQLPDYNR IRSGMFWLRF
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