About Bifunctional purine biosynthesis protein ATIC
Bifunctional purine biosynthesis protein ATIC (ATIC) is a protein
from Homo sapiens identified by UniProt accession
P31939, 592 residues long.
MolForge cross-references it against 0 known binders and
180 disease associations.
Target properties
| Protein name | Bifunctional purine biosynthesis protein ATIC |
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| UniProt accession | P31939 |
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| Gene | ATIC |
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| Organism | Homo sapiens |
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| Length | 592 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (180)
Diseases linked to this target (Open Targets).
- AICA-ribosiduria · score 0.70
- cancer · score 0.57
- Intellectual disability · score 0.46
- lung adenocarcinoma · score 0.39
- anaplastic large cell lymphoma · score 0.37
- squamous cell lung carcinoma · score 0.37
- neurofibrillary tangles measurement · score 0.31
- Macular dystrophy · score 0.30
- large cell lung carcinoma · score 0.28
- adenosquamous lung carcinoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31939-F1 | alphafold | PREDICTED | 97.36 | — |
Amino-acid sequence (592 residues)
MAPGQLALFS VSDKTGLVEF ARNLTALGLN LVASGGTAKA LRDAGLAVRD VSELTGFPEM LGGRVKTLHP AVHAGILARN IPEDNADMAR LDFNLIRVVA CNLYPFVKTV ASPGVTVEEA VEQIDIGGVT LLRAAAKNHA RVTVVCEPED YVVVSTEMQS SESKDTSLET RRQLALKAFT HTAQYDEAIS DYFRKQYSKG VSQMPLRYGM NPHQTPAQLY TLQPKLPITV LNGAPGFINL CDALNAWQLV KELKEALGIP AAASFKHVSP AGAAVGIPLS EDEAKVCMVY DLYKTLTPIS AAYARARGAD RMSSFGDFVA LSDVCDVPTA KIISREVSDG IIAPGYEEEA LTILSKKKNG NYCVLQMDQS YKPDENEVRT LFGLHLSQKR NNGVVDKSLF SNVVTKNKDL PESALRDLIV ATIAVKYTQS NSVCYAKNGQ VIGIGAGQQS RIHCTRLAGD KANYWWLRHH PQVLSMKFKT GVKRAEISNA IDQYVTGTIG EDEDLIKWKA LFEEVPELLT EAEKKEWVEK LTEVSISSDA FFPFRDNVDR AKRSGVAYIA APSGSAADKV VIEACDELGI ILAHTNLRLF HH
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