About DNA dC->dU-editing enzyme APOBEC-3A
DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A) is a protein
from Homo sapiens identified by UniProt accession
P31941, 199 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | DNA dC->dU-editing enzyme APOBEC-3A |
|---|
| UniProt accession | P31941 |
|---|
| Gene | APOBEC3A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 199 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (128)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- breast carcinoma · score 0.36
- mean corpuscular hemoglobin · score 0.26
- HbA1c measurement · score 0.26
- breast cancer · score 0.24
- HER2 negative breast carcinoma · score 0.21
- urinary bladder carcinoma · score 0.20
- breast neoplasm · score 0.18
- blood protein measurement · score 0.17
- cutaneous melanoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31941-F1 | alphafold | PREDICTED | 86.89 | — |
Amino-acid sequence (199 residues)
MEASPASGPR HLMDPHIFTS NFNNGIGRHK TYLCYEVERL DNGTSVKMDQ HRGFLHNQAK NLLCGFYGRH AELRFLDLVP SLQLDPAQIY RVTWFISWSP CFSWGCAGEV RAFLQENTHV RLRIFAARIY DYDPLYKEAL QMLRDAGAQV SIMTYDEFKH CWDTFVDHQG CPFQPWDGLD EHSQALSGRL RAILQNQGN
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