Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)

About Heterogeneous nuclear ribonucleoprotein H

Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) is a protein from Homo sapiens identified by UniProt accession P31943, 449 residues long. MolForge cross-references it against 0 known binders and 203 disease associations.

Target properties

Protein name	Heterogeneous nuclear ribonucleoprotein H
UniProt accession	P31943
Gene	HNRNPH1
Organism	Homo sapiens
Length	449 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (203)

Diseases linked to this target (Open Targets).

genetic disorder · score 0.40
Neurodevelopmental disorder · score 0.37
intellectual disability, X-linked, syndromic, Bain type · score 0.27
lung adenocarcinoma · score 0.23
pancreatic adenocarcinoma · score 0.23
breast adenocarcinoma · score 0.23
multiple myeloma · score 0.21
neutrophil percentage of leukocytes · score 0.20
lymphocyte percentage of leukocytes · score 0.20
cutaneous melanoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31943-F1	alphafold	PREDICTED	61.89	—

Amino-acid sequence (449 residues)

MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDFQSNIA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards