About Caspase-14
Caspase-14 (CASP14) is a protein
from Homo sapiens identified by UniProt accession
P31944, 242 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | Caspase-14 |
|---|
| UniProt accession | P31944 |
|---|
| Gene | CASP14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 242 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (114)
Diseases linked to this target (Open Targets).
- Ichthyosis-hypotrichosis syndrome · score 0.47
- glioblastoma multiforme · score 0.23
- head and neck squamous cell carcinoma · score 0.19
- thyroid gland adenocarcinoma · score 0.19
- ovarian cancer · score 0.18
- clear cell renal carcinoma · score 0.18
- gastric adenocarcinoma · score 0.16
- bronchitis · score 0.13
- low grade glioma · score 0.11
- squamous cell lung carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31944-F1 | alphafold | PREDICTED | 89.08 | — |
Amino-acid sequence (242 residues)
MSNPRSLEEE KYDMSGARLA LILCVTKARE GSEEDLDALE HMFRQLRFES TMKRDPTAEQ FQEELEKFQQ AIDSREDPVS CAFVVLMAHG REGFLKGEDG EMVKLENLFE ALNNKNCQAL RAKPKVYIIQ ACRGEQRDPG ETVGGDEIVM VIKDSPQTIP TYTDALHVYS TVEGYIAYRH DQKGSCFIQT LVDVFTKRKG HILELLTEVT RRMAEAELVQ EGKARKTNPE IQSTLRKRLY LQ
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