About 14-3-3 protein beta/alpha
14-3-3 protein beta/alpha (YWHAB) is a protein
from Homo sapiens identified by UniProt accession
P31946, 246 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | 14-3-3 protein beta/alpha |
|---|
| UniProt accession | P31946 |
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| Gene | YWHAB |
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| Organism | Homo sapiens |
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| Length | 246 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (97)
Diseases linked to this target (Open Targets).
- cancer · score 0.59
- Noonan syndrome · score 0.56
- Costello syndrome · score 0.54
- hypertrophic cardiomyopathy · score 0.54
- neurodegenerative disease · score 0.53
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- lean body mass · score 0.33
- basophil count · score 0.33
- mean platelet volume · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31946-F1 | alphafold | PREDICTED | 93.43 | — |
Amino-acid sequence (246 residues)
MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN
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