About 14-3-3 protein sigma
14-3-3 protein sigma (SFN) is a protein
from Homo sapiens identified by UniProt accession
P31947, 248 residues long.
MolForge cross-references it against 0 known binders and
705 disease associations.
Target properties
| Protein name | 14-3-3 protein sigma |
|---|
| UniProt accession | P31947 |
|---|
| Gene | SFN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 248 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (705)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- glioblastoma multiforme · score 0.29
- breast adenocarcinoma · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- squamous cell lung carcinoma · score 0.27
- urinary bladder cancer · score 0.27
- hepatocellular carcinoma · score 0.19
- sex hormone-binding globulin measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31947-F1 | alphafold | PREDICTED | 92.89 | — |
Amino-acid sequence (248 residues)
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
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