Low affinity immunoglobulin gamma Fc region…

About Low affinity immunoglobulin gamma Fc region receptor II-b

Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is a protein from Homo sapiens identified by UniProt accession P31994, 310 residues long. MolForge cross-references it against 0 known binders and 828 disease associations.

Target properties

Protein name	Low affinity immunoglobulin gamma Fc region receptor II-b
UniProt accession	P31994
Gene	FCGR2B
Organism	Homo sapiens
Length	310 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (828)

Diseases linked to this target (Open Targets).

systemic lupus erythematosus · score 0.40
total blood protein measurement · score 0.40
blood protein measurement · score 0.38
hemoglobin measurement · score 0.38
head and neck squamous cell carcinoma · score 0.37
thyroid carcinoma · score 0.37
breast ductal adenocarcinoma · score 0.37
birth weight · score 0.36
low affinity immunoglobulin gamma Fc region receptor II-a/b measurement · score 0.34
neutrophil count · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31994-F1	alphafold	PREDICTED	78.44	—

Amino-acid sequence (310 residues)

MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA LEEPDDQNRI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)