About Beta-arrestin-2
Beta-arrestin-2 (ARRB2) is a protein
from Homo sapiens identified by UniProt accession
P32121, 409 residues long.
MolForge cross-references it against 0 known binders and
192 disease associations.
Target properties
| Protein name | Beta-arrestin-2 |
|---|
| UniProt accession | P32121 |
|---|
| Gene | ARRB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 409 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (192)
Diseases linked to this target (Open Targets).
- cancer · score 0.59
- Noonan syndrome · score 0.53
- hypertrophic cardiomyopathy · score 0.50
- Costello syndrome · score 0.50
- cardiofaciocutaneous syndrome · score 0.37
- lymphocyte count · score 0.30
- breast adenocarcinoma · score 0.29
- lung adenocarcinoma · score 0.28
- endometrial cancer · score 0.28
- low grade glioma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32121-F1 | alphafold | PREDICTED | 83.80 | — |
Amino-acid sequence (409 residues)
MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC
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