Glycerol kinase (GK)

About Glycerol kinase

Glycerol kinase (GK) is a protein from Homo sapiens identified by UniProt accession P32189, 559 residues long. MolForge cross-references it against 0 known binders and 182 disease associations.

Target properties

Protein name	Glycerol kinase
UniProt accession	P32189
Gene	GK
Organism	Homo sapiens
Length	559 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (182)

Diseases linked to this target (Open Targets).

inborn glycerol kinase deficiency · score 0.71
Glycerol kinase deficiency · score 0.64
isolated glycerol kinase deficiency · score 0.52
glycerol kinase deficiency, juvenile form · score 0.37
glycerol kinase deficiency, adult form · score 0.37
genetic disorder · score 0.33
Global developmental delay · score 0.12
Absent speech · score 0.12
Seizure · score 0.12
azoospermia · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32189-F1	alphafold	PREDICTED	91.65	—

Amino-acid sequence (559 residues)

MAASKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE GWVEQDPKEI LHSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW DKITGEPLYN AVVWLDLRTQ STVESLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VRKVQKAVEE KRALFGTIDS WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PNVRSSSEIY GLMKISHSVK AGALEGVPIS GCLGDQSAAL VGQMCFQIGQ AKNTYGTGCF LLCNTGHKCV FSDHGLLTTV AYKLGRDKPV YYALEGSVAI AGAVIRWLRD NLGIIKTSEE IEKLAKEVGT SYGCYFVPAF SGLYAPYWEP SARGIICGLT QFTNKCHIAF AALEAVCFQT REILDAMNRD CGIPLSHLQV DGGMTSNKIL MQLQADILYI PVVKPSMPET TALGAAMAAG AAEGVGVWSL EPEDLSAVTM ERFEPQINAE ESEIRYSTWK KAVMKSMGWV TTQSPESGDP SIFCSLPLGF FIVSSMVMLI GARYISGIP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards