Cholecystokinin receptor type A (CCKAR)

About Cholecystokinin receptor type A

Cholecystokinin receptor type A (CCKAR) is a protein from Homo sapiens identified by UniProt accession P32238, 428 residues long. MolForge cross-references it against 0 known binders and 180 disease associations.

Target properties

Protein name	Cholecystokinin receptor type A
UniProt accession	P32238
Gene	CCKAR
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (180)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.37
gastroesophageal reflux disease · score 0.37
Peptic ulcer · score 0.37
neurodegenerative disease · score 0.30
irritable bowel syndrome · score 0.26
glioblastoma multiforme · score 0.26
breast adenocarcinoma · score 0.25
appendicular lean mass · score 0.17
BMI-adjusted waist-hip ratio · score 0.17
waist-hip ratio · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32238-F1	alphafold	PREDICTED	77.69	—

Amino-acid sequence (428 residues)

MDVVDSLLVN GSNITPPCEL GLENETLFCL DQPRPSKEWQ PAVQILLYSL IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICKPLQSR VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTANMCRFLL PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI KFEASQKKSA KERKPSTTSS GKYEDSDGCY LQKTRPPRKL ELRQLSTGSS SRANRIRSNS SAANLMAKKR VIRMLIVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT PISFILLLSY TSSCVNPIIY CFMNKRFRLG FMATFPCCPN PGPPGARGEV GEEEEGGTTG ASLSRFSYSH MSASVPPQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards