Homeobox protein OTX1 (OTX1)

About Homeobox protein OTX1

Homeobox protein OTX1 (OTX1) is a protein from Homo sapiens identified by UniProt accession P32242, 354 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.

Target properties

Protein name	Homeobox protein OTX1
UniProt accession	P32242
Gene	OTX1
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (153)

Diseases linked to this target (Open Targets).

prostate carcinoma · score 0.46
lean body mass · score 0.30
social interaction measurement · score 0.29
diet measurement · score 0.27
fat body mass · score 0.26
risk-taking behaviour · score 0.25
vitamin D measurement · score 0.25
whole body water mass · score 0.17
age at first sexual intercourse measurement · score 0.16
balding measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32242-F1	alphafold	PREDICTED	56.35	—

Amino-acid sequence (354 residues)

MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG SGTKSRPAKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSSSANPA AAAAAGLGGN PVAAASSLST PAASSIWSPA SISPGSAPAS VSVPEPLAAP SNTSCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPTPSS SYFGGVDCSS YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH HQGYGGSGLA FNSADCLDYK EPGAAAASSA WKLNFNSPDC LDYKDQASWR FQVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards