Homeobox protein OTX2 (OTX2)

About Homeobox protein OTX2

Homeobox protein OTX2 (OTX2) is a protein from Homo sapiens identified by UniProt accession P32243, 289 residues long. MolForge cross-references it against 0 known binders and 461 disease associations.

Target properties

Protein name	Homeobox protein OTX2
UniProt accession	P32243
Gene	OTX2
Organism	Homo sapiens
Length	289 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (461)

Diseases linked to this target (Open Targets).

syndromic microphthalmia type 5 · score 0.82
pituitary hormone deficiency, combined, 6 · score 0.72
Combined pituitary hormone deficiencies, genetic forms · score 0.66
anophthalmia-microphthalmia syndrome · score 0.55
alcohol consumption measurement · score 0.48
Anophthalmia · score 0.47
agnathia-otocephaly complex · score 0.46
cortical surface area measurement · score 0.42
Retinal dystrophy · score 0.42
genetic disorder · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32243-F1	alphafold	PREDICTED	59.69	—

Amino-acid sequence (289 residues)

MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP AKKKTSPARE VSSESGTSGQ FTPPSSTSVP TIASSSAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD CGSYLTPMHH QLPGPGATLS PMGTNAVTSH LNQSPASLST QGYGASSLGF NSTTDCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards