Bombesin receptor subtype-3 (BRS3)

About Bombesin receptor subtype-3

Bombesin receptor subtype-3 (BRS3) is a protein from Homo sapiens identified by UniProt accession P32247, 399 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Bombesin receptor subtype-3
UniProt accession	P32247
Gene	BRS3
Organism	Homo sapiens
Length	399 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
ovarian cancer · score 0.26
breast adenocarcinoma · score 0.25
head and neck squamous cell carcinoma · score 0.16
obesity due to melanocortin 4 receptor deficiency · score 0.08
severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency · score 0.06
obesity due to prohormone convertase I deficiency · score 0.05
obesity due to pro-opiomelanocortin deficiency · score 0.05
type 2 diabetes mellitus · score 0.05
obesity due to congenital leptin deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32247-F1	alphafold	PREDICTED	78.94	—

Amino-acid sequence (399 residues)

MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI YITYAVIISV GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC VPVDATHYLA EGWLFGRIGC KVLSFIRLTS VGVSVFTLTI LSADRYKAVV KPLERQPSNA ILKTCVKAGC VWIVSMIFAL PEAIFSNVYT FRDPNKNMTF ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI ARTLYKSTLN IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA ERPEPPVADT SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards