G-protein coupled receptor 183 (GPR183)

About G-protein coupled receptor 183

G-protein coupled receptor 183 (GPR183) is a protein from Homo sapiens identified by UniProt accession P32249, 361 residues long. MolForge cross-references it against 0 known binders and 220 disease associations.

Target properties

Protein name	G-protein coupled receptor 183
UniProt accession	P32249
Gene	GPR183
Organism	Homo sapiens
Length	361 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (220)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.31
eosinophil count · score 0.22
asthma · score 0.21
lymphocyte percentage of leukocytes · score 0.21
childhood onset asthma · score 0.20
basal cell carcinoma · score 0.18
multiple sclerosis · score 0.16
type 1 diabetes mellitus · score 0.16
eosinophil percentage of leukocytes · score 0.16
psoriasis · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32249-F1	alphafold	PREDICTED	86.54	—

Amino-acid sequence (361 residues)

MDIQMANNFT PPSATPQGND CDLYAHHSTA RIVMPLHYSL VFIIGLVGNL LALVVIVQNR KKINSTTLYS TNLVISDILF TTALPTRIAY YAMGFDWRIG DALCRITALV FYINTYAGVN FMTCLSIDRF IAVVHPLRYN KIKRIEHAKG VCIFVWILVF AQTLPLLINP MSKQEAERIT CMEYPNFEET KSLPWILLGA CFIGYVLPLI IILICYSQIC CKLFRTAKQN PLTEKSGVNK KALNTIILII VVFVLCFTPY HVAIIQHMIK KLRFSNFLEC SQRHSFQISL HFTVCLMNFN CCMDPFIYFF ACKGYKRKVM RMLKRQVSVS ISSAVKSAPE ENSREMTETQ MMIHSKSSNG K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards