About G protein-coupled receptor kinase 4
G protein-coupled receptor kinase 4 (GRK4) is a protein
from Homo sapiens identified by UniProt accession
P32298, 578 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | G protein-coupled receptor kinase 4 |
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| UniProt accession | P32298 |
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| Gene | GRK4 |
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| Organism | Homo sapiens |
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| Length | 578 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (63)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.40
- cigarettes per day measurement · score 0.38
- self reported educational attainment · score 0.27
- vital capacity · score 0.27
- diet measurement · score 0.23
- blood protein measurement · score 0.23
- neurodegenerative disease · score 0.22
- mathematical ability · score 0.21
- body fat percentage · score 0.15
- smoking behaviour measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32298-F1 | alphafold | PREDICTED | 88.66 | — |
Amino-acid sequence (578 residues)
MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE KDYSSLCDKQ PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD CGLSILDRFF NDKLAAPLPE IPPDVVTECR LGLKEENPSK KAFEECTRVA HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ PVTKNTFRHY RVLGKGGFGE VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE KVQSRFVVSL AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV GYMAPEVVNN EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ RIKNDTEEYS EKFSEDAKSI CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK DINFRRLEAN MLEPPFCPDP HAVYCKDVLD IEQFSVVKGI YLDTADEDFY ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK NIHTPVSRPN RGFFYRLFRR GGCLTMVPSE KEVEPKQC
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