Forkhead box protein N2 (FOXN2)

About Forkhead box protein N2

Forkhead box protein N2 (FOXN2) is a protein from Homo sapiens identified by UniProt accession P32314, 431 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	Forkhead box protein N2
UniProt accession	P32314
Gene	FOXN2
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
sex hormone-binding globulin measurement · score 0.40
vital capacity · score 0.40
serum alanine aminotransferase measurement · score 0.37
HbA1c measurement · score 0.37
serum gamma-glutamyl transferase measurement · score 0.36
body height · score 0.36
mathematical ability · score 0.35
alkaline phosphatase measurement · score 0.33
body fat percentage · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32314-F1	alphafold	PREDICTED	60.33	—

Amino-acid sequence (431 residues)

MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST AKTQNQKQRK K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards