About Guanylate-binding protein 1
Guanylate-binding protein 1 (GBP1) is a protein
from Homo sapiens identified by UniProt accession
P32455, 592 residues long.
MolForge cross-references it against 0 known binders and
355 disease associations.
Target properties
| Protein name | Guanylate-binding protein 1 |
|---|
| UniProt accession | P32455 |
|---|
| Gene | GBP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 592 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (355)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- Neutrophil inclusion bodies · score 0.26
- acute myeloid leukemia · score 0.20
- inflammatory bowel disease · score 0.13
- neoplasm · score 0.11
- glioblastoma multiforme · score 0.10
- cancer · score 0.10
- infection · score 0.09
- infect · score 0.09
- breast cancer · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32455-F1 | alphafold | PREDICTED | 91.27 | — |
Amino-acid sequence (592 residues)
MASEIHMTGP MCLIENTNGR LMANPEALKI LSAITQPMVV VAIVGLYRTG KSYLMNKLAG KKKGFSLGST VQSHTKGIWM WCVPHPKKPG HILVLLDTEG LGDVEKGDNQ NDSWIFALAV LLSSTFVYNS IGTINQQAMD QLYYVTELTH RIRSKSSPDE NENEVEDSAD FVSFFPDFVW TLRDFSLDLE ADGQPLTPDE YLTYSLKLKK GTSQKDETFN LPRLCIRKFF PKKKCFVFDR PVHRRKLAQL EKLQDEELDP EFVQQVADFC SYIFSNSKTK TLSGGIQVNG PRLESLVLTY VNAISSGDLP CMENAVLALA QIENSAAVQK AIAHYEQQMG QKVQLPTETL QELLDLHRDS EREAIEVFIR SSFKDVDHLF QKELAAQLEK KRDDFCKQNQ EASSDRCSAL LQVIFSPLEE EVKAGIYSKP GGYRLFVQKL QDLKKKYYEE PRKGIQAEEI LQTYLKSKES MTDAILQTDQ TLTEKEKEIE VERVKAESAQ ASAKMLQEMQ RKNEQMMEQK ERSYQEHLKQ LTEKMENDRV QLLKEQERTL ALKLQEQEQL LKEGFQKESR IMKNEIQDLQ TKMRRRKACT IS
Explore Guanylate-binding protein 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets