About Guanylate-binding protein 2
Guanylate-binding protein 2 (GBP2) is a protein
from Homo sapiens identified by UniProt accession
P32456, 591 residues long.
MolForge cross-references it against 0 known binders and
279 disease associations.
Target properties
| Protein name | Guanylate-binding protein 2 |
|---|
| UniProt accession | P32456 |
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| Gene | GBP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 591 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (279)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- thyroid gland adenocarcinoma · score 0.18
- inflammatory bowel disease · score 0.17
- nonpapillary renal cell carcinoma · score 0.10
- breast cancer · score 0.08
- neoplasm · score 0.08
- pancreatic adenocarcinoma · score 0.08
- triple-negative breast cancer · score 0.08
- subarachnoid hemorrhage · score 0.07
- familial atrial fibrillation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32456-F1 | alphafold | PREDICTED | 89.31 | — |
Amino-acid sequence (591 residues)
MAPEINLPGP MSLIDNTKGQ LVVNPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KKNGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDIEKGDNE NDSWIFALAI LLSSTFVYNS MGTINQQAMD QLHYVTELTD RIKANSSPGN NSVDDSADFV SFFPAFVWTL RDFTLELEVD GEPITADDYL ELSLKLRKGT DKKSKSFNDP RLCIRKFFPK RKCFVFDWPA PKKYLAHLEQ LKEEELNPDF IEQVAEFCSY ILSHSNVKTL SGGIPVNGPR LESLVLTYVN AISSGDLPCM ENAVLALAQI ENSAAVEKAI AHYEQQMGQK VQLPTETLQE LLDLHRDSER EAIEVFMKNS FKDVDQMFQR KLGAQLEARR DDFCKQNSKA SSDCCMALLQ DIFGPLEEDV KQGTFSKPGG YRLFTQKLQE LKNKYYQVPR KGIQAKEVLK KYLESKEDVA DALLQTDQSL SEKEKAIEVE RIKAESAEAA KKMLEEIQKK NEEMMEQKEK SYQEHVKQLT EKMERDRAQL MAEQEKTLAL KLQEQERLLK EGFENESKRL QKDIWDIQMR SKSLEPICNI L
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