About 4-hydroxyphenylpyruvate dioxygenase
4-hydroxyphenylpyruvate dioxygenase (HPD) is a protein
from Homo sapiens identified by UniProt accession
P32754, 393 residues long.
MolForge cross-references it against 0 known binders and
171 disease associations.
Target properties
| Protein name | 4-hydroxyphenylpyruvate dioxygenase |
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| UniProt accession | P32754 |
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| Gene | HPD |
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| Organism | Homo sapiens |
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| Length | 393 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (171)
Diseases linked to this target (Open Targets).
- Tyrosinemia type 3 · score 0.78
- tyrosinemia type III · score 0.76
- hawkinsinuria · score 0.75
- tyrosinemia · score 0.45
- mean corpuscular volume · score 0.30
- mean platelet volume · score 0.29
- Hypertyrosinemia · score 0.29
- alkaptonuria · score 0.29
- 2-hydroxyisobutyrate measurement · score 0.28
- Spasticity · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32754-F1 | alphafold | PREDICTED | 95.72 | — |
Amino-acid sequence (393 residues)
MTTYSDKGAK PERGRFLHFH SVTFWVGNAK QATSFYCSKM GFEPLAYRGL ETGSREVVSH VIKQGKIVFV LSSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCDYIVQKA RERGAKIMRE PWVEQDKFGK VKFAVLQTYG DTTHTLVEKM NYIGQFLPGY EAPAFMDPLL PKLPKCSLEM IDHIVGNQPD QEMVSASEWY LKNLQFHRFW SVDDTQVHTE YSSLRSIVVA NYEESIKMPI NEPAPGKKKS QIQEYVDYNG GAGVQHIALK TEDIITAIRH LRERGLEFLS VPSTYYKQLR EKLKTAKIKV KENIDALEEL KILVDYDEKG YLLQIFTKPV QDRPTLFLEV IQRHNHQGFG AGNFNSLFKA FEEEQNLRGN LTNMETNGVV PGM
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