About General transcription factor IIH subunit 1
General transcription factor IIH subunit 1 (GTF2H1) is a protein
from Homo sapiens identified by UniProt accession
P32780, 548 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | General transcription factor IIH subunit 1 |
|---|
| UniProt accession | P32780 |
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| Gene | GTF2H1 |
|---|
| Organism | Homo sapiens |
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| Length | 548 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.59
- mean platelet volume · score 0.34
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.24
- glioblastoma multiforme · score 0.23
- serum amyloid A protein measurement · score 0.22
- blood metabolite measurement · score 0.21
- squamous cell lung carcinoma · score 0.19
- head and neck squamous cell carcinoma · score 0.18
- lung adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32780-F1 | alphafold | PREDICTED | 73.90 | — |
Amino-acid sequence (548 residues)
MATSSEEVLL IVKKVRQKKQ DGALYLMAER IAWAPEGKDR FTISHMYADI KCQKISPEGK AKIQLQLVLH AGDTTNFHFS NESTAVKERD AVKDLLQQLL PKFKRKANKE LEEKNRMLQE DPVLFQLYKD LVVSQVISAE EFWANRLNVN ATDSSSTSNH KQDVGISAAF LADVRPQTDG CNGLRYNLTS DIIESIFRTY PAVKMKYAEN VPHNMTEKEF WTRFFQSHYF HRDRLNTGSK DLFAECAKID EKGLKTMVSL GVKNPLLDLT ALEDKPLDEG YGISSVPSAS NSKSIKENSN AAIIKRFNHH SAMVLAAGLR KQEAQNEQTS EPSNMDGNSG DADCFQPAVK RAKLQESIEY EDLGKNNSVK TIALNLKKSD RYYHGPTPIQ SLQYATSQDI INSFQSIRQE MEAYTPKLTQ VLSSSAASST ITALSPGGAL MQGGTQQAIN QMVPNDIQSE LKHLYVAVGE LLRHFWSCFP VNTPFLEEKV VKMKSNLERF QVTKLCPFQE KIRRQYLSTN LVSHIEEMLQ TAYNKLHTWQ SRRLMKKT
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