About Cystathionine gamma-lyase
Cystathionine gamma-lyase (CTH) is a protein
from Homo sapiens identified by UniProt accession
P32929, 405 residues long.
MolForge cross-references it against 0 known binders and
267 disease associations.
Target properties
| Protein name | Cystathionine gamma-lyase |
|---|
| UniProt accession | P32929 |
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| Gene | CTH |
|---|
| Organism | Homo sapiens |
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| Length | 405 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (267)
Diseases linked to this target (Open Targets).
- cystathioninuria · score 0.75
- colorectal cancer · score 0.22
- colon carcinoma · score 0.22
- genetic disorder · score 0.19
- inflammatory bowel disease · score 0.17
- glioblastoma multiforme · score 0.09
- neoplasm · score 0.09
- hepatocellular carcinoma · score 0.09
- Sepsis · score 0.08
- retinitis pigmentosa · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32929-F1 | alphafold | PREDICTED | 95.78 | — |
Amino-acid sequence (405 residues)
MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGHSDV VMGLVSVNCE SLHNRLRFLQ NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS
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