About Intercellular adhesion molecule 3
Intercellular adhesion molecule 3 (ICAM3) is a protein
from Homo sapiens identified by UniProt accession
P32942, 547 residues long.
MolForge cross-references it against 0 known binders and
161 disease associations.
Target properties
| Protein name | Intercellular adhesion molecule 3 |
|---|
| UniProt accession | P32942 |
|---|
| Gene | ICAM3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 547 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (161)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.22
- systemic lupus erythematosus · score 0.22
- multiple myeloma · score 0.22
- rheumatoid arthritis · score 0.21
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.18
- platelet-to-lymphocyte ratio · score 0.17
- IGF-1 measurement · score 0.16
- cutaneous melanoma · score 0.11
- psoriatic arthritis · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32942-F1 | alphafold | PREDICTED | 87.12 | — |
Amino-acid sequence (547 residues)
MATMVPSVLW PRACWTLLVC CLLTPGVQGQ EFLLRVEPQN PVLSAGGSLF VNCSTDCPSS EKIALETSLS KELVASGMGW AAFNLSNVTG NSRILCSVYC NGSQITGSSN ITVYRLPERV ELAPLPPWQP VGQNFTLRCQ VEDGSPRTSL TVVLLRWEEE LSRQPAVEEP AEVTATVLAS RDDHGAPFSC RTELDMQPQG LGLFVNTSAP RQLRTFVLPV TPPRLVAPRF LEVETSWPVD CTLDGLFPAS EAQVYLALGD QMLNATVMNH GDTLTATATA TARADQEGAR EIVCNVTLGG ERREARENLT VFSFLGPIVN LSEPTAHEGS TVTVSCMAGA RVQVTLDGVP AAAPGQPAQL QLNATESDDG RSFFCSATLE VDGEFLHRNS SVQLRVLYGP KIDRATCPQH LKWKDKTRHV LQCQARGNPY PELRCLKEGS SREVPVGIPF FVNVTHNGTY QCQASSSRGK YTLVVVMDIE AGSSHFVPVF VAVLLTLGVV TIVLALMYVF REHQRSGSYH VREESTYLPL TSMQPTEAMG EEPSRAE
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