About CD70 antigen
CD70 antigen (CD70) is a protein
from Homo sapiens identified by UniProt accession
P32970, 193 residues long.
MolForge cross-references it against 0 known binders and
313 disease associations.
Target properties
| Protein name | CD70 antigen |
|---|
| UniProt accession | P32970 |
|---|
| Gene | CD70 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 193 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (313)
Diseases linked to this target (Open Targets).
- severe combined immunodeficiency due to CD70 deficiency · score 0.61
- Combined immunodeficiency · score 0.46
- combined immunodeficiency · score 0.46
- lymphoproliferative syndrome · score 0.45
- asthma · score 0.35
- neurodegenerative disease · score 0.24
- acute myeloid leukemia · score 0.24
- genetic disorder · score 0.19
- lymphocyte count · score 0.17
- neoplasm · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32970-F1 | alphafold | PREDICTED | 83.21 | — |
Amino-acid sequence (193 residues)
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN TDETFFGVQW VRP
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