About Long-chain-fatty-acid--CoA ligase 1
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) is a protein
from Homo sapiens identified by UniProt accession
P33121, 698 residues long.
MolForge cross-references it against 0 known binders and
188 disease associations.
Target properties
| Protein name | Long-chain-fatty-acid--CoA ligase 1 |
|---|
| UniProt accession | P33121 |
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| Gene | ACSL1 |
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| Organism | Homo sapiens |
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| Length | 698 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (188)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.47
- mean platelet volume · score 0.43
- glucose measurement · score 0.43
- age at menopause · score 0.41
- HbA1c measurement · score 0.38
- neurodegenerative disease · score 0.37
- platelet crit · score 0.36
- diabetes mellitus · score 0.36
- mean reticulocyte volume · score 0.34
- hemoglobin A1 measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P33121-F1 | alphafold | PREDICTED | 90.30 | — |
Amino-acid sequence (698 residues)
MQAHELFRYF RMPELVDFRQ YVRTLPTNTL MGFGAFAALT TFWYATRPKP LKPPCDLSMQ SVEVAGSGGA RRSALLDSDE PLVYFYDDVT TLYEGFQRGI QVSNNGPCLG SRKPDQPYEW LSYKQVAELS ECIGSALIQK GFKTAPDQFI GIFAQNRPEW VIIEQGCFAY SMVIVPLYDT LGNEAITYIV NKAELSLVFV DKPEKAKLLL EGVENKLIPG LKIIVVMDAY GSELVERGQR CGVEVTSMKA MEDLGRANRR KPKPPAPEDL AVICFTSGTT GNPKGAMVTH RNIVSDCSAF VKATENTVNP CPDDTLISFL PLAHMFERVV ECVMLCHGAK IGFFQGDIRL LMDDLKVLQP TVFPVVPRLL NRMFDRIFGQ ANTTLKRWLL DFASKRKEAE LRSGIIRNNS LWDRLIFHKV QSSLGGRVRL MVTGAAPVSA TVLTFLRAAL GCQFYEGYGQ TECTAGCCLT MPGDWTAGHV GAPMPCNLIK LVDVEEMNYM AAEGEGEVCV KGPNVFQGYL KDPAKTAEAL DKDGWLHTGD IGKWLPNGTL KIIDRKKHIF KLAQGEYIAP EKIENIYMRS EPVAQVFVHG ESLQAFLIAI VVPDVETLCS WAQKRGFEGS FEELCRNKDV KKAILEDMVR LGKDSGLKPF EQVKGITLHP ELFSIDNGLL TPTMKAKRPE LRNYFRSQID DLYSTIKV
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