About Cleavage stimulation factor subunit 2
Cleavage stimulation factor subunit 2 (CSTF2) is a protein
from Homo sapiens identified by UniProt accession
P33240, 577 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Cleavage stimulation factor subunit 2 |
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| UniProt accession | P33240 |
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| Gene | CSTF2 |
|---|
| Organism | Homo sapiens |
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| Length | 577 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.19
- chronic lymphocytic leukemia · score 0.15
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.10
- cancer · score 0.09
- non-small cell lung carcinoma · score 0.02
- laryngotracheoesophageal cleft · score 0.02
- infection · score 0.02
- infect · score 0.02
- bladder transitional cell carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P33240-F1 | alphafold | PREDICTED | 59.81 | — |
Amino-acid sequence (577 residues)
MAGLTVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGTGAPV IESPYGETIS PEDAPESISK AVASLPPEQM FELMKQMKLC VQNSPQEARN MLLQNPQLAY ALLQAQVVMR IVDPEIALKI LHRQTNIPTL IAGNPQPVHG AGPGSGSNVS MNQQNPQAPQ AQSLGGMHVN GAPPLMQASM QGGVPAPGQM PAAVTGPGPG SLAPGGGMQA QVGMPGSGPV SMERGQVPMQ DPRAAMQRGS LPANVPTPRG LLGDAPNDPR GGTLLSVTGE VEPRGYLGPP HQGPPMHHVP GHESRGPPPH ELRGGPLPEP RPLMAEPRGP MLDQRGPPLD GRGGRDPRGI DARGMEARAM EARGLDARGL EARAMEARAM EARAMEARAM EARAMEVRGM EARGMDTRGP VPGPRGPIPS GMQGPSPINM GAVVPQGSRQ VPVMQGTGMQ GASIQGGSQP GGFSPGQNQV TPQDHEKAAL IMQVLQLTAD QIAMLPPEQR QSILILKEQI QKSTGAP
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