Cytochrome P450 2C18 (CYP2C18)

About Cytochrome P450 2C18

Cytochrome P450 2C18 (CYP2C18) is a protein from Homo sapiens identified by UniProt accession P33260, 490 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Cytochrome P450 2C18
UniProt accession	P33260
Gene	CYP2C18
Organism	Homo sapiens
Length	490 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

response to anticoagulant · score 0.37
clopidogrel metabolite measurement · score 0.36
neurodegenerative disease · score 0.30
bilirubin measurement · score 0.30
alkaline phosphatase measurement · score 0.29
platelet reactivity measurement · score 0.24
response to clopidogrel · score 0.24
unipolar depression · score 0.21
response to selective serotonin reuptake inhibitor · score 0.21
blood metabolite measurement · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P33260-F1	alphafold	PREDICTED	93.84	—

Amino-acid sequence (490 residues)

MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM SKSLTNFSKV YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF PVAEKVNKGL GILFSNGKRW KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHDRFDYK DQRFLNLMEK FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI KSYVLERIKE HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA VVHEIQRYID LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE FPNPEMFDPG HFLDKSGNFK KSDYFMPFSA GKRMCMGEGL ARMELFLFLT TILQNFNLKS QVDPKDIDIT PIANAFGRVP PLYQLCFIPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards