Cyclin-dependent kinases regulatory subunit 2 (CKS2)

About Cyclin-dependent kinases regulatory subunit 2

Cyclin-dependent kinases regulatory subunit 2 (CKS2) is a protein from Homo sapiens identified by UniProt accession P33552, 79 residues long. MolForge cross-references it against 0 known binders and 272 disease associations.

Target properties

Protein name	Cyclin-dependent kinases regulatory subunit 2
UniProt accession	P33552
Gene	CKS2
Organism	Homo sapiens
Length	79 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (272)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
reticulocyte count · score 0.15
platelet crit · score 0.15
mean corpuscular volume · score 0.12
platelet count · score 0.12
Female infertility due to fertilization defect · score 0.10
hepatocellular carcinoma · score 0.10
cancer · score 0.10
azoospermia · score 0.09
Rare genetic female infertility · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P33552-F1	alphafold	PREDICTED	92.52	—

Amino-acid sequence (79 residues)

MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH EPEPHILLFR RPLPKDQQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards