T-lymphocyte activation antigen CD80 (CD80)

About T-lymphocyte activation antigen CD80

T-lymphocyte activation antigen CD80 (CD80) is a protein from Homo sapiens identified by UniProt accession P33681, 288 residues long. MolForge cross-references it against 0 known binders and 682 disease associations.

Target properties

Protein name	T-lymphocyte activation antigen CD80
UniProt accession	P33681
Gene	CD80
Organism	Homo sapiens
Length	288 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (682)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.60
psoriatic arthritis · score 0.53
juvenile idiopathic arthritis · score 0.53
acute graft vs. host disease · score 0.50
immune system disease · score 0.46
COVID-19 · score 0.45
dermatomyositis · score 0.45
diabetes mellitus · score 0.39
cancer · score 0.39
primary biliary cirrhosis · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P33681-F1	alphafold	PREDICTED	86.14	—

Amino-acid sequence (288 residues)

MGHTRRQGTS PSKCPYLNFF QLLVLAGLSH FCSGVIHVTK EVKEVATLSC GHNVSVEELA QTRIYWQKEK KMVLTMMSGD MNIWPEYKNR TIFDITNNLS IVILALRPSD EGTYECVVLK YEKDAFKREH LAEVTLSVKA DFPTPSISDF EIPTSNIRRI ICSTSGGFPE PHLSWLENGE ELNAINTTVS QDPETELYAV SSKLDFNMTT NHSFMCLIKY GHLRVNQTFN WNTTKQEHFP DNLLPSWAIT LISVNGIFVI CCLTYCFAPR CRERRRNERL RRESVRPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards